FDA approved Botox for Multiple Sclerosis induced incontinence. Time Magazine published an article Wednesday.
What exactly is Botox?
Famous as a symbol of vanity, Botox is an abbreviation for Botulinum Toxin which actually has medicinal uses. Botox is FDA approved to treat chronic migraines, muscle problems, underarm sweating and a number of other conditions. Now add to that, urinary incontinence.
On Wednesday, the U.S. Food and Drug Administration (FDA) approved Botox to treat incontinence in patients with neurological conditions like spinal cord injury and multiple sclerosis.
Botox, a muscle-relaxing medication used to decrease spasticity related to multiple sclerosis and other neurological conditions. Botox is derived from the bacterium Clostridium botulinum and is in a class of drugs called neurotoxins. There are three types of botulinum toxins available for therapeutic use:
• OnabotulinumtoxinA (Botox/Botox Cosmetic)
• RimabotulinumtoxinB (Myobloc)
• AbobotulinumtoxinA (Dysport)
OnabotulinumtoxinA is the Botox approved for urinary incontinence.
How does it treat urinary incontinence? In some patients with neurological conditions, over activity in the bladder leads to an inability to store urine. By injecting Botox directly into the bladder to relax it, patients are offered more muscle control and less incontinence.
In two clinical trials involving 691 patients with incontinence due to spinal cord injury or multiple sclerosis, those who got Botox had a significant reduction in weekly incontinence episodes, compared to a placebo group, the FDA said. The most common adverse effects were urinary tract infection and urinary retention.
Given that incontinence is so difficult to manage — typically involving drugs to relax the bladder and the use of a catheter to empty it — Botox may give some patients another option.
One injection may help control incontinence for up to 10 months, the FDA said.
The approval also opens the door to yet more uses for Botox, made by Allergan, the New York Times reported.
The drug has been studied for more than 100 medical conditions in all, according to Caroline Van Hove, company spokeswoman. “Anything from writer’s cramp to anal fissure to Parkinson’s disease. That’s why we say it’s a pipeline in a vial,” she said Wednesday.
In my mind, urinary incontinence is the ultimate embarrassment living a life with multiple sclerosis
I thought this medication might possibly work to lessen this problem and save my ego, but with further research I learned that Botox is a treatment only used as a last resort! Botox actually weakens the bladder and is only tried after a suprapubic Catheter has been used.