by Dani Price
Histamine, as defined in The Merriam Webster Dictionary, is “a compound widespread in many animal tissues that plays a major role in allergic reactions”. Although most individuals see histamines as a problem, ground breaking research published in the Journal of Leukocyte Biology has found that histamine could be beneficial in new treatments for Multiple Sclerosis, or MS.
“Histamine is a neurotransmitter involved in allergic reactions and other physiological and pathological processes. It is best known for the role it plays in hypersensitivity reactions like allergies, and it generally works by dilating blood vessels and making vessel walls permeable so immune cells can move more easily. Scientists studied the direct effects of histamine and two similar molecules that bind specifically on histamine receptors 1 or 2.”
According to this research, in tests done on animals with symptoms similar to MS, histamine played a vital role in preventing or reducing the effects. A mouse model of MS was used to test histamine along with two other molecules. Armenian Medical Network shared the results that were evaluated and they show that “histamine reduces the proliferation of myelin auto-reactive T lymphocytes and the production of interferon-gamma” The Interferon-gamma is a critical cytokine that contributes to brain inflammation and the destruction of myelin. The histamine also reduced a critical step in the development of MS by lessening the ability of the myelin auto-reactive T cells to cling to the inflamed brain vessels.
This research is very exciting for two reasons.
First, it points to unexpected connection between pathways involved in autoimmunity and allergy and suggests previously unrecognized connections between these very different types of immune responses.
Second, while extending studies in animal models such as these to humans takes substantially more work, these new data point to a potentially novel drug target for MS and possibly other autoimmune or central nervous system diseases,’ said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology.”
This news is very exciting to the MS community because its evidence that Elaine Delack knew what she was doing when she created ProKarin!
About the author:
Dani Jane Price was 9 years old when her mom was diagnosed with MS. She graduated with a bachelors degree in Child and Family Development from Southern Virginia University. Dani is happily married to a wonderful husband of 5 years and dedicates her time to nurture and raise her two beautiful daughters. Dani is a talented singer, enjoys music and participates in the community.