Transcription Factors: How Genes are Regulated

Transcription Factors Broad Institute explains what transcription factors are, “Transcription factors are proteins that control which genes are turned on or off in the genome. They do so by binding to DNA and other proteins. Once bound to DNA, these proteins can promote or block the enzyme that controls the reading, or “transcription,” of genes, making genes more or less active.

Transcription factors are essential for the regulation of genes. For example, different genes are turned on in liver cells than in skin cells. Different genes are turned on in cancer cells than in healthy cells. Through the action of transcription factors, the various cells of the body, which all have the same genome, can function differently.

These proteins are so important to life that they are found in all living organisms. Roughly 8% of genes in the human genome encode transcription factors. They play important roles in development, the sending of signals within the cell, and the events in a cell that lead to division and duplication, known as the cell cycle. Several human diseases are linked to mutations in transcription factors, such as diabetes, autoimmune diseases, and cancer.”

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About our Co-Founder: With a bachelors in Social Work, Linda is 53 years old, happily married with eight children and 17 grandchildren. Diagnosed with MS in 1995 and now having accepted and truly embraced her new reality, Linda has created MSrelief.com. She is dedicated to proving that joy can be chosen while living with Multiple Sclerosis. Linda specializes in helping others, especially those with MS attain the lifestyle, independence and happiness amid living with MS.

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